Kam Yeung, Ph.D


Kam Yeung is currently an Associate Professor in the Department of Biochemistry & Cancer Biology at the University of Toledo Health Science Campus, Toledo, OH, USA. In 1986 he earned his Bsc in Basic Medical Sciences from the University of South Alabama, Mobile, Al and in 1990 his Ph.D in Microbiology from the same University. Kam performed his postdoctoral training in Molecular Virology and Biochemistry at the University of Iowa, Iowa City, IA and HHMI/UMDNJ, Piscataway, NJ. His research training and independent research have been in the broad area of transcription regulation and cell signaling with emphasis focused on how the dyregulation of these processes lead to cancer. Kam, in collaboration withJohn Sedivy and Walter Kolch, made the initial discovery of Raf Kinase Inhibitor Protein (RKIP) as a negative regulator of the activity of the Raf/MEK/Erk kinase module. His studies demonstrated that RKIP regulates the Ras/Raf/MEK/Erk module by inhibiting the phosphorylation and activation of MEK by Raf-1. RKIP is not a substrate for Raf-1 or MEK, but competitively disrupts the interaction between these kinases. His contributions on RKIP field provide a new handle for understanding the etiology of cancer in molecular detail and initiates studies aimed to dissect the complex regulatory pathways that drive cancer initiation and progression. Curremtly Kam is working on exploring the role of microRNAs in the regulation of RKIP suppression in breast cancer.

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